A U.S.-bound plane carrying five Americans, previously imprisoned in Iran, has left Doha following a rare prisoner swap deal.
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Iran has also released five Iranians held in the United States as part of the exchange.
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The swap included the transfer of $6 billion in Iranian funds, with the money being moved from South Korea to Qatar.
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U.S. President Joe Biden hailed the release of the American detainees as a humanitarian action.
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Iran's President Ebrahim Raisi described the exchange as a "humanitarian action" and expressed hope for future similar actions.
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The swap has raised questions about whether it could lead to progress on other issues, including Iran's nuclear program.
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U.S. Secretary of State Antony Blinken left the possibility of future diplomacy on the nuclear file open but noted that there were no current engagements.
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Fresh U.S. sanctions were announced against Iran's former president Mahmoud Ahmadinejad and its intelligence ministry.
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The prisoner exchange was facilitated through mediation by Qatar and assistance from Switzerland and South Korea.
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Some U.S. officials expressed concerns that the $6 billion exchange might incentivize Iran to take more U.S. citizens hostage.
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