Colts' QB Anthony Richardson is cleared from the concussion protocol and will start against the Rams.
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Left tackle Bernhard Raimann enters concussion protocol, and the Colts will be without at least one offensive lineman.
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Either rookie Blake Freeland or backup Arlington Hambright will start at left tackle in Raimann's absence.
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Center Ryan Kelly, who missed the previous game, practiced but failed to clear the concussion protocol on Friday.
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Wesley French may start at center if Ryan Kelly is officially ruled out, as backup Danny Pinter is out for the season with an ankle injury.
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Right tackle Braden Smith missed Friday's practice with a hand injury, and his status for the game remains uncertain.
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All-Pro guard Quenton Nelson returned to practice after missing two sessions due to a toe injury.
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All-Pro defensive tackle DeForest Buckner missed the entire week of practice with a groin injury.
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The makeshift offensive line faces the formidable challenge of defending against the Rams and star defender Aaron Donald.
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The Colts aim to better protect QB Anthony Richardson, who has faced injury questions in his first two starts.
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